Every rule, that governs a randomized clinical trial originally came from some study that had a disastrous outcome. Somebody made a mistake and the results did not replicate or they turned out to be wrong and then some methodologist took a look at why this happened and thought about, well what can we do in the future to prevent this ever happening again? And all of these rules are based on real experiences with research and data and they are all meant to prevent consequences that they know about.
To learn more from Dr. Helena Kraemer listen to the podcast episode below.
Randomized Clinical Trials Part 1
Randomized Clinical Trials Part 2