Department of Genetics
Dr. Xin Zhou received his Ph.D. on Genetics and Genome Sciences from University of Connecticut Health Center and The Jackson Laboratory for Genomic Medicine. He was trained under the Integrative Human Microbiome Project (https://www.hmpdacc.org/ihmp/ ) and have a particular focus on deciphering the complex interaction between human microbiome and the immune system. His work demonstrated an interaction between immune system and members from class Clostridia might improve the epithelium barrier integrity and therefore prevent the inflammation related to the onset and progression of insulin resistance.
Xin works at Department of Genetics at Stanford University exploring the systematic dynamics between human microbiome, transcriptome, immunome, lipidome, and metabolome during health and disease progression.
SAGE Project: Relating gastrointestinal dysbiosis in pulmonary arterial hypertension to rapid vascular aging
Pulmonary arterial hypertension (PAH) is characterized by increased blood pressure in the lungs and often with pathological thickening of arterial vessel wall. It was recently proposed the chronic inflammation-related vascular aging may contribute to the onset and development of PAH. This project will examine if altered gut microbiome-immune interactions is one of the common confounding factors between these two highly correlated phenotypes. Furthermore, we will identify specific microbial signatures in serum that could mechanistically explain the causational effect of dysbiosis towards low grade chronic inflammation—“inflammaging”.