Department of Medicine – Cardiovascular Medicine; Department of Pediatrics – Cardiology
Dr. Clarke is a preventive cardiologist and an instructor at Stanford University School of Medicine in the Departments of Medicine and Pediatrics. He earned his undergraduate degree in human biology from the Division of Nutritional Sciences at Cornell University before obtaining his MD and PhD (genetics) from Stanford University School of Medicine. He has completed clinical training in internal medicine (Brigham & Women’s Hospital), pediatrics (Boston Children’s Hospital), and cardiovascular medicine (Stanford Hospital), and he is board certified in all three specialties. His research is focused on
- Understanding complex disease genetics in diverse populations,
- Integrating monogenic and polygenic risk with clinical risk,
- Large-scale phenotyping using the electronic health record.
His clinical practice focuses on identifying risk factors for cardiovascular disease with the goal of promoting health and longevity through evidence-based personalized treatment. He is interested in developing family-centric approaches for the treatment of adults and children carrying high genetic risk for disease.
SAGE Project: Development and analysis of a telomere length resource for ethnogeriatric studies of older adults in the Million Veteran Program
Telomere length has been associated with several age-related chronic illnesses, including atherosclerosis and cognitive decline. Both genetics and environmental exposures impact TL. However, telomere length has been predominantly studied in European populations, and biobanks with telomere length data have little representation of ethnogeriatric populations. The goal of this project is to leverage the Million Veteran Program (MVP)—an EHR-linked biobank of U.S. veterans that is more diverse, older, and carries more comorbidities compared to other available national biobanks—to develop a telomere resource for ethnogeriatric studies. Dr. Clarke and Dr. Kruthika Iyer (co-investigator) collaboratively developed and executed this project.