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Bootstrap Methodology

What do you do when you have a set of observations, you don’t know what the distribution is, but you have a certain question, for example I want to test between two populations and I don’t know what the distributions in either are? What you do is, if you have let’s say 10 observations in the sample, drop one and then compute statistic, put it back, drop a second one computer statistic. At the end if your 10 observations, you have 10 what are called jackknife estimates. Each one is obtained by dropping one of the original observations. Though the jackknife method actually worked very well for a lot of cases and it was the method of choice for quite a long time, it also had some problems. It didn’t work very well with small samples and it didn’t work if you were dealing with data where there were a lot of ties. But then when we got to about the 80s, and the 90s, that’s when the bootstrap method came out. 

To learn more from Dr. Helena Kraemer listen to the podcast episode below.

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    Next-Generation Artificial Intelligence for Diagnosis: From Predicting Diagnostic Labels to "Wayfinding"

    Julia Adler-Milstein, PhD1; Jonathan H. Chen, MD, PhD; Gurpreet Dhaliwal, MD

    Improving the diagnostic process is a quality and safety priority.With the digitization of health records and rapid expansion of health data, the cognitive demand on the diagnostician has increased. The use of artificial intelligence (AI) to assist human cognition has the potential to reduce this demand and associated diagnostic errors. However, current AI tools have not realized this potential, due in part to the long-standing focus of these tools on predicting final diagnostic labels instead of helping clinicians navigate the dynamic refinement process of diagnosis. This Viewpoint highlights the importance of shifting the role of diagnostic AI from predicting labels to “wayfinding” (interpreting context and providing cues that guide the diagnostician).